Visual OMP^TM 7.0 Upgrade Released to All Customers

ANN ARBOR, MI – May 8, 2009 – DNA Software, Inc. is pleased to announce the release of Visual OMP^TM 7.0, which contains the new Modifieds^TM module that enables secondary structure analysis and simulation of hybridization-based experiments with oligonucleotides containing modified nucleotides.

Modifieds^TM

Modified nucleotides are commonly used for: (1) designing probes with high sensitivity and specificity, (2) designing siRNAs with high efficacy, and (3) performing assays of epigenetic gene regulation.

DNA Software’s new Modifieds^TM module is a unique software product that helps a user to develop optimally sensitive and selective assays, siRNAs, and hybridization-based technologies.  The Modifieds^TM module predicts secondary structure and determines hybridization efficiency for oligonucleotides containing modified nucleotides.  DNA Software conducted extensive wet lab studies to derive a comprehensive set of nearest neighbor thermodynamic parameters for each modified nucleotide.  This extensive, proprietary database of parameters makes Modifieds^TM an exceptionally accurate tool for in silico modeling.  Accordingly, the predictions generated by Modifieds^TM accurately match experiments results.  Modifieds^TM currently includes LNA, PNA, Morpholino, Deoxyuridine-DNA, Inosine, Isocytosine, Isoguanine.  Moreover, DNA Software is continuing to derive additional thermodynamic parameters for many more modified nucleotides in its wet lab.  These extra parameters will be released to DNA Software’s customers and as part of the Modifieds^TM license.

Visual OMP^TM 7.0 Upgrade Summary

New Features: 

 Enhancements:

• Improved BLAST capability
• New licensing systems with increased flexibility

For a complete list of all of the features of the new version, please visit our Version History page.   

About DNA Software, Inc.

DNA Software, Inc. was founded in 2000 to commercialize the advances in nucleic acid chemistry discovered by world-renowned expert Dr. John SantaLucia, Jr. (the company’s Chief Scientific Officer). DNA Software’s technologies have become the standard of excellence for nucleic acid research and diagnostics development. 

DNA Software is a unique software company considering that it conducts original wet lab research. The company’s software programs are the most accurate and comprehensive tools available because its advanced algorithms and models are driven by a large database of thousands of diverse, wet lab-derived, experimental results. DNA Software’s tools correctly design and simulate complicated experiments on the first attempt. Customers can simulate thousands of experiments with the software before running a single experiment in a wet lab. Thus, DNA Software’s technologies save customers significant time, resources, and money that would have been wasted on trial-and-error experimentation. 

DNA Software offers contract research, custom software development, commercial web applications, and scientific consulting for nucleic acid research. The company also licenses packaged software tools that help scientists quickly and accurately develop new assays, diagnostics, and therapeutics. OMP^TM (Oligonucleotide Modeling Platform^TM), the core engine that runs all of DNA Software’s tools, models in silico the folding and hybridization of nucleic acids with exception accuracy. Visual OMP^TM is a platform program for the analysis of nucleic acid secondary structure plus the design, simulation, and optimization of probes/primers, RT-PCR, qPCR, Multiplex PCR, Taqman, Beacons, Scorpions, Microarrays, SNP detection, FRET assays, RNAi, LATE-PCR, plus new formats. ThermoBLAST^TM quickly and accurately scans DNA, or RNA oligonucleotides against large genome databases, identifies all hybridizations under actual reaction conditions, and detects all extensible, off-target amplicons. The Modifieds^TM module adds modified nucleotides (e.g. LNA, PNA, Morpholino, Deoxyuridine-DNA, Inosine, Isocytosine, Isoguanine, plus many more) to OMP^TM and ThermoBLAST^TM. OMP Developer Edition^TM (OMP DE^TM) and ThermoBLAST Developer Edition^TM (TB DE^TM) bring customizable, command line, high-throughput computing power to large assay design and genome scanning projects or enterprise applications. 

The company has expanded its original DNA and RNA-based, molecular biology solutions to include modified nucleotides, oligonucleotide kinetics, and structural biology. 

For more information, please contact DNA Software at +1 734 222 9080, info@dnasoftware.com, or www.dnasoftware.com.