Visual OMP 6.0 Released
Ann Arbor, Mich. – December 15, 2006
—DNA Software proudly announces the release of Visual OMP version
6.0.0.
Included in the new release, besides minor bug fixes and interface
improvements, is the ability to use the "universal"
base Inosine in simulation resulting from research conducted
in the SantaLucia lab, and improved predictions for DNA-RNA
interactions resulting from an NIH-finded grant project conducted
at DNA Software.
Inosine will help Visual OMP users in predicting the hybridization
characteristics of degenerate primers and probes. There is a
variety of applications in which inosine can be of great value.
Inosine can be used in microarray applications to increase the
stability of a library of oligos without increasing the diversity
of the library, and in electrochemical based DNA-hybridization
guanine in the probe is usually replaced by inosine so that
a much higher electrochemical signal is observed.
The incorporation of the most accurate RNA-DNA structural motif
parameters to date into Visual OMP enables researchers to optimize
their complex assays involving DNA-RNA hybridization, like gene-specific
RT-PCR, RNA antisense technology and in situ hybridization of
mRNA, in silico, thereby significantly reducing the cost and
time of new assay development.
The graphs below show the increased dG prediction accuracy for
RNA-DNA mismatch duplexes of Visual OMP 6.0.0 as compared to
Visual OMP 5.0.5. Observed dG is plotted versus dG predicted
by Visual OMP for 200 duplexes. The R-squared value increased
from 0.691 to 0.922 after incorporating the updated DNA-RNA
parameters into OMP.
For a complete list of all of the features of the new version,
please visit our Version
History page.
About DNA Software, Inc.
DNA Software, Inc. combines science and software
to enable industrial genomics through advances in technologies
based on nucleic acids. The company’s first software platform,
OMP (Oligonucleotide Modeling Platform,) models in silico
the folding and hybridization of single-stranded nucleic acids
with great accuracy. The company combines OMP with scientific
consulting, custom software development, and custom laboratory
research to deliver state-of-the-art support for designing and
developing of nucleic acid based technologies. For more information
on DNA Software, Inc., visit our website at http://www.dnasoftware.com.
CONTACT:
DNA Software, Inc.
204 East Washington Street
Ann Arbor, MI 48104
Office: +1 (734) 222-9080
Toll-Free: +1 (877) 362-7638
Fax: +1 (734) 222-9087
Email: info@dna-software.com
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