Based on 10 years of scientific research led by our chief scientist, John SantaLucia, OMP contains a comprehensive thermodynamic database derived from hundreds of empirical observations.

Accounting for every important structural motif and a sequence dependent model for hairpins help ensure the most accurate model available anywhere. No other software offers such a complete model of nucleic acid hybridization.

Go Beyond Naïve Tm
Most software only caclulates simple 2-state thermodynamics. However, the competing target and primer structures significantly affect the thermodynamics. OMP uses a novel numerical procedure to solve this complex coupled equilibrium problem. This multi-state model results in a more accurate "effective" thermodynamic prediction.

Check for Extensibility
Identify potential sources of noise in PCR reactions.