Based
on 10 years of scientific research led by our chief scientist,
John SantaLucia, OMP contains a comprehensive thermodynamic
database derived from hundreds of empirical observations.
Accounting for every important structural motif and a sequence
dependent model for hairpins help ensure the most accurate
model available anywhere. No other software offers such
a complete model of nucleic acid hybridization.
Go Beyond Naïve Tm
Most software only caclulates simple 2-state thermodynamics.
However, the competing target and primer structures significantly
affect the thermodynamics. OMP uses a novel numerical procedure
to solve this complex coupled equilibrium problem. This
multi-state model results in a more
accurate "effective" thermodynamic prediction.
Check for Extensibility
Identify potential sources of noise in PCR reactions.
