Tools and Technology
We offer a portfolio of technologies that enable our customers to develop diagnostic assays and therapeutics with unrivaled sensitivity and specificity.
DNAS Designer: is the oligo design engine for our cloud applications. Proprietary algorithms developed by DNAS accurately predict the folding and other properties of the candidate probes and primers that it generates. This crucial information enables our cloud software to rank and select from the best candidates for each application. As Designer reveals the design “sweet spots” within target secondary structure, the applications can choose the most sensitive and specific probes and primers for its needs.
DNAS Simulator :is the experiment simulation engine for our cloud applications. Its proprietary folding algorithms developed by DNAS accurately predict the behavior and interactions between oligos and targets under your experimental conditions. This allows the cloud software to predict and avoid undesirable outcomes such as unwanted secondary structure or oligo to oligo mishybridization, which is vital for selecting the best solutions.
Modifieds™: DNA Software™ has assembled the world’s most comprehensive thermodynamic database of modified nucleotides through a series of NIH grants and has incorporated these parameters into our simulation and design of oligos.
OligoKS™: The Oligo Kinetics Simulator, OligoKS™, predicts rate kinetics from sequence and represents a breakthrough in our understanding of Oligonucleotide hybridization kinetics and competing unimolecular folding. important to several assay formats including fast cycling PCR and microarray probe hybridization.
ThermoBLAST™: scans oligos across collection of genomes to detect all false positive hybridizations and amplicons, resulting in better specificity of assays.
CopyCount: turns every qPCR reaction into an absolute PCR determination, without the need for a standard curve, and without changing instruments. CopyCount saves money by reducing reagents costs, number of replicates, and laborious standard curves.
Heuristics: DNAS captures expert knowledge in the form of algorithmic rules or strategies to effectively identify the best solutions, filtering these from the vast sea of possibilities.